مقايسه اثرات فسفاژنيك و اسيد لاكتيك بر نشانگرهاي IGF1 و IGFBP3 در شناگران حرفهاي رده سني 11 تا 16 سال

Introduction: Growth hormone (GH) an‎d insulin-like growth factor-1 (IGF-1), along with IGF binding protein-3 (IGFBP-3), play vital roles in growth, muscle development, an‎d metabolic regulation in adolescents. Given the importance of anaerobic energy system training, this study aimed to compare the effects of phosphagen system an‎d lactic acid system training on serum levels of IGF-1 an‎d IGFBP-3 in elite swimmers aged 11 to 16 years. Methods an‎d Material: In this pre-post experimental study, 36 elite adolescent swimmers were ran‎domly assigned into three groups: control, phosphagen training, an‎d lactic acid training (12 participants each). The training interventions lasted for 8 weeks, with three sessions per week. Venous blood samples were collected at baseline an‎d post-intervention, an‎d serum IGF-1 an‎d IGFBP-3 levels were measured using specific ELISA kits. Data were analyzed using paired t-tests, one-way ANOVA, an‎d repeated measures ANOVA. Results: Statistical analysis indicated no significant within-group changes in IGF-1 levels after the intervention; however, significant differences were observed between groups post-training (p=0.008). IGFBP-3 levels decreased significantly in both phosphagen an‎d lactic acid training groups (p<‎0.01), with no significant differences between these groups. The findings suggest distinct hormonal responses to each type of training an‎d an overall reduction in IGFBP-3, possibly as an adaptive response to training load. Conclusion: Phosphagen an‎d lactic acid system trainings differently affect IGF-1 an‎d IGFBP-3 levels, an‎d the significant reduction in IGFBP-3 may enhance IGF-1 bioavailability, facilitating anabolic processes. Careful monitoring of these biochemical markers can be effective in designing optimized training programs to support healthy growth an‎d athletic performance in adolescents. Key words: adolescent swimmers, IGF-1, IGFBP-3, phosphagen training, lactic acid training, growth hormone, anaerobic exercise

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